Ischemia

Ischemia is an insufficient supply of oxygenated blood to an organ, usually due to a blocked artery.

Myocardial ischemia is an intermediate condition in coronary artery disease during which the heart tissue is slowly or suddenly starved of oxygen and other nutrients. Eventually, the affected heart tissue will die.

When blood flow is completely blocked to the heart, ischemia can lead to a heart attack. Ischemia can be silent or symptomatic. According to the American Heart Association, up to four million Americans may have silent ischemia and be at high risk of having a heart attack with no warning.

Symptomatic ischemia is characterized by chest pain called angina pectoris. The American Heart Association estimates that nearly seven million Americans have angina pectoris, usually called angina.

Angina occurs more frequently in women than in men, and more often in African-Americans and Hispanics than in Caucasians. It also occurs more frequently as people age 25% of women over the age of 85 and 27% of men between 80 and 84 years of age have angina.

People with angina are at risk of having a heart attack. Stable angina occurs during exertion, can be quickly relieved by resting or taking nitroglycerine, and lasts from three to 20 minutes.

Unstable angina, which increases the risk of a heart attack, occurs more frequently, lasts longer, is more severe, and may cause discomfort during rest or light exertion.

Ischemia also can occur in the arteries of the brain, where blockages can lead to a stroke. About 80–85% of all strokes are ischemic. Most blockages in the cerebral arteries are due to a blood clot, often in an artery narrowed by plaque.

Sometimes, a blood clot in the heart or aorta travels to a cerebral artery. A transient ischemic attack (TIA) is a “mini-stroke” caused by a temporary deficiency of blood supply to the brain, or by a blood clot briefly blocking a cerebral artery.

It occurs suddenly, lasts a few minutes to a few hours, and is a strong warning sign of an impending stroke. Ischemia can also affect intestines, legs, feet, and kidneys. Pain, malfunctions, and damage in those areas may result.

Causes and symptoms

Ischemia almost always is caused by blockage of an artery, usually due to atherosclerotic plaque. Myocardial ischemia also is caused by blood clots (which tend to form on plaque), artery spasms or contractions, or any of these factors combined. Silent ischemia usually is caused by emotional or mental stress or by exertion, but there are no symptoms.


Angina usually is caused by increased oxygen demand when the heart is working harder than usual, for example, during exercise, or during mental or physical stress. According to researchers at Harvard University, physical stress is harder on the heart than mental stress.

Risk factors

The risk factors for myocardial ischemia are the same as those for coronary artery disease, TIA, and stroke:
  • Heredity. People whose parents have coronary artery disease are more likely to develop it. African-Americans also are at higher risk.
  • Sex. Men are more likely to have heart attacks than women, and to have them at a younger age. Angina is more likely to occur in women.
  • Age. Men who are 45 years of age and older and women who are 55 years of age and older are considered to be at risk. Risk also increases with age.
  • Smoking. Smoking increases both the chance of developing coronary artery disease and the chance of dying from it. Secondhand smoke also may increase risk.
  • High cholesterol levels. Risk of developing coronary artery disease increases as blood cholesterol levels increase. When combined with other factors, the risk is even greater.
  • High blood pressure. High blood pressure makes the heart work harder, and with time, weakens it. When combined with obesity, smoking, high cholesterol levels, or diabetes, the risk of heart attack or stroke increases several times.
  • High fibrinogen levels. Fibrinogens are the proteins involved in blood clotting and plaque formation.
  • High homeocysteine levels. Homeocysteine also is involved in plaque formation.
  • Oxidant damage, as indicated by high lipid peroxide levels. High lipid peroxide levels represent a high level of free radical damage and antioxidant deficiency.
  • Lack of physical activity. Lack of exercise increases the risk of coronary artery disease.
  • Diabetes mellitus. The risk of developing coronary artery disease is seriously increased for diabetics.
  • Obesity. Excess weight increases the strain on the heart and increases the risk of developing coronary artery disease, even if no other risk factors are present. Obesity increases blood pressure and blood cholesterol, and can lead to diabetes.
  • Stress and anger. Some scientists believe that stress and anger can contribute to the development of coronary artery disease. Stress increases the heart rate and blood pressure and can injure the lining of the arteries. Angina attacks often occur after outbursts of anger, as do many heart attacks and strokes.

Angina symptoms include:
  • a tight, squeezing, heavy, burning, or choking pain that is usually beneath the breastbone—the pain may spread to the throat, jaw, or one arm
  • a feeling of heaviness or tightness that is not painful
  • a feeling similar to gas or indigestion
  • attacks brought on by exertion and relieved by rest

If the pain or discomfort continues or intensifies, immediate medical help should be sought, ideally within 30 minutes.

TIA symptoms include:
  • sudden weakness, tingling, or numbness, usually in one arm or leg or both the arm and leg on the same side of the body, as well as sometimes in the face
  • sudden loss of coordination
  • loss of vision or double vision
  • difficulty speaking
  • vertigo and loss of balance

Diagnosis

Diagnostic tests for myocardial ischemia include: resting, exercise, or ambulatory electrocardiograms; scintigraphic studies (radioactive heart scans); echocardiography; coronary angiography; and, rarely, positron emission tomography.

Diagnostic tests for TIA include physician review of symptoms, computed tomography (CT) scans, carotid artery ultrasound (Doppler ultrasonography), and magnetic resonance imaging (MRI). Angiography is the best test for ischemia of any organ.

An electrocardiogram (ECG) shows the heart’s activity and may reveal a lack of oxygen. Electrodes covered with conducting jelly are placed on the patient’s chest, arms, and legs. Impulses of the heart’s activity are recorded on paper.

The test takes about 10 minutes and is performed in a physician’s office. About 25% of patients with angina have normal electrocardiograms. Another type of electrocardiogram, the exercise stress test, measures response to exertion when the patient is exercising on a treadmill or a stationary bike.

It is performed in a physician’s office or an exercise laboratory and takes 15–30 minutes. This test is more accurate than a resting ECG in diagnosing ischemia. Sometimes an ambulatory ECG is ordered. For this test, the patient wears a portable ECG machine called a Holter monitor for 12, 24, or 48 hours.

Myocardial perfusion scintigraphy and radionuclide angiography are nuclear studies involving the injection of a radioactive material (e.g., thallium), that is absorbed by healthy tissue. A gamma scintillation camera displays and records a series of images of the radioactive material’s movement through the heart.

Both tests usually are performed in a hospital’s nuclear medicine department and take about 30 minutes to an hour. A perfusion scan sometimes is performed at the end of a stress test.

An echocardiogram uses sound waves to create an image of the heart’s chambers and valves. The technologist applies gel to a handheld transducer, then presses it against the patient’s chest.

The heart’s sound waves are converted into an image on a monitor. Performed in a cardiology outpatient diagnostic laboratory, the test takes 30 minutes to an hour. It can reveal abnormalities in the heart wall that indicate ischemia, but it does not evaluate the coronary arteries directly.

Coronary angiography is the most accurate diagnostic technique, but it also is the most invasive. It shows the heart’s chambers, great vessels, and coronary arteries by using a contrast solution and x-ray technology.

A moving picture is recorded of the blood flow through the coronary arteries. The patient is awake, but sedated, and connected to ECG electrodes and an intravenous line.

A local anesthetic is injected. The cardiologist then inserts a catheter into a blood vessel and guides it into the heart. Coronary angiography is performed in a cardiac catheterization laboratory and takes from 30 minutes to two hours.

Positron emission tomography (PET) is a noninvasive nuclear test used to evaluate the heart tissue. A PET scanner traces high-energy gamma rays released from radioactive particles to provide three-dimensional images of the heart tissue. Performed at a hospital, it usually takes from one hour to one hour and 45 minutes. CT and MRI are computerized scanning methods.

CT scanning uses a thin x-ray beam to show three-dimensional views of soft tissues. It is performed at a hospital or clinic and takes only minutes. MRI uses a magnetic field to produce clear, cross-sectional images of soft tissues. The patient lies on a table that slides into a tunnel-like scanner for about 30 minutes.

Treatment

Ischemia can be life-threatening. Although there are alternative treatments for angina, traditional medical care may be necessary. Prevention of the cause of ischemia, primarily atherosclerosis, is primary. This becomes even more important for people with a family history of heart disease.

Nutritional therapy

Dietary modifications are essential in the treatment and prevention of ischemic heart disease. The following dietary changes are recommended:
  • Limiting intake of red meat and animal fats that contain high amounts of cholesterol and saturated fats.
  • Eating a heart-wise diet with emphasis on fresh fruits and vegetables, grains, beans, and nuts. Increased fiber (found in fresh fruits and vegetables, grains, and beans) can help the body eliminate excessive cholesterol through the stools.
  • Avoiding coffee (caffienated and decaffeinated) and smoking. Not smoking will prevent damage from smoke and the harmful substances (oxidants) it contains.
  • Taking high-potency multivitamin/mineral supplement (one tablet daily). Heart patients may require higher amounts of antioxidants, such as vitamins C and E. They should aim for total daily intake of 500–1,000 mg of vitamin C and 400–800 IU of (natural) vitamin E. They also should take 1 tbsp of flaxseed oil or fish oil per day. Flaxseed oil is a good source of omega-3 oils. Numerous studies have demonstrated the cardio-protective effects of omega-3 fatty acids.
  • Considering supplements for specific health problems. Individuals with diabetes might benefit from chromium, garlic, and pantethine supplements. Niacin, flaxseed oil, and garlic help treat elevated fibrinogen levels. For those with high homocysteine levels, vitamin B6,B12, and folic acid may be needed. Patients with high lipid peroxide levels require more antioxidants to prevent free radical damage. Antioxidants, such as vitamins C and E, selenium, Ginkgo biloba, bilberry (Vaccinium myrtillus), and hawthorn, can help prevent initial arterial injury that can lead to the formation of plaque deposits. In fact, a 2001 report indicated that patients saw clinical improvements in exercise tolerance, fatigue, and shortness of breath when using hawthorn extract.

Herbal therapy

Western herbal medicine recommends hawthorn (Crataegus laevigata or C. oxyacantha) to help prevent long-term angina, since this herb strengthens heart muscles’ ability to contract.

Homeopathy

Cactus grandiflorus is a homeopathic remedy made from night-blooming cactus and used for pain relief during an attack.

Ayurvedic medicine

Abana, a mixture of herbs and minerals used in Ayurvedic medicine, may reduce the frequency and severity of angina attacks.

Exercises

Exercise, particularly aerobic exercise, is essential for circulation health. It is recommended that the patient exercise for 20 minutes, three times a week.

Mind/body medicine

Mind/body relaxation techniques such as yoga, meditation, stress reduction, and biofeedback can help control strong emotions and stress.

Chelation therapy

The use of chelation therapy, a long-term injection by a physician of a cocktail of synthetic amino acid, ethylenediaminetetracetic acid, and anticoagulant drugs and nutrients, is controversial.

Allopathic treatment

Angina is treated with drug therapy and surgery. Drugs such as nitrates, beta-blockers, and calcium channel blockers relieve chest pain, but they cannot clear blocked arteries. In 2003, it was reported that administering testosterone to men with myocardial ischemia helped reduce the ischemia.

Another study in patients with Type II diabetes used intensive therapy combining lifestyle interventions, aspirin and such dietary supplements as vitamins E and C, as well as certain prescribed drugs.

These patients showed fewer cardiovascular events such as heart attack and stroke, than those treated more conservatively. Aspirin helps prevent blood clots. Surgical procedures include percutaneous transluminal coronary angioplasty and coronary artery bypass graft surgery.

Nitroglycerin is the classic treatment for angina. It quickly relieves pain and discomfort by opening the coronary arteries and allowing more blood to flow to the heart. Beta-blockers reduce the amount of oxygen required by the heart during stress.

Calcium channel blockers help keep the arteries open and reduce blood pressure. Aspirin helps prevent blood clots from forming on plaques. Statins help reduce cholesterol levels, which can lessen ischemic events.

Percutaneous transluminal coronary angioplasty and coronary artery bypass graft surgery are invasive procedures that improve blood flow in the coronary arteries.

Percutaneous transluminal coronary angioplasty is a nonsurgical procedure in which a catheter tipped with a balloon is threaded from a blood vessel in the thigh into the blocked artery.

The balloon is inflated, compressing the plaque to enlarge the blood vessel and open the blocked artery. The balloon is deflated and the catheter is removed. Sometimes a metal stent is placed in the artery to prevent closing.

In coronary artery bypass graft, called bypass surgery, a detour is built around the coronary artery blockage with a healthy leg vein or chest wall artery. The healthy vein or artery then supplies oxygen-rich blood to the heart.

Bypass surgery is major surgery appropriate for patients with blockages in two or three major coronary arteries or severely narrowed left main coronary arteries, as well as those who have not responded to other treatments.

There are several experimental surgical procedures: atherectomy, in which the surgeon shaves off and removes strips of plaque from the blocked artery; laser angioplasty, in which a catheter with a laser tip is inserted to burn or break down the plaque; and insertion of a metal coil, called a stent, that can be implanted permanently to keep a blocked artery open.

This stenting procedure is becoming more common. An experimental procedure uses a laser to drill channels in the heart muscle to increase blood supply.

TIAs are treated by drugs that control high blood pressure and reduce the likelihood of blood clots and surgery. Aspirin is commonly used and anticoagulants are sometimes used to prevent blood clots.

In some cases, carotid endarterectomy surgery is performed to help prevent further TIAs. The procedure involves removing arterial plaque from inside blood vessels.

Expected results

In many cases, ischemia can be successfully treated, but the underlying disease process of atherosclerosis is usually not “cured.” New diagnostic techniques enable doctors to identify ischemia earlier.

New technologies and surgical procedures can prevent angina from leading to a heart attack or TIA from resulting in a stroke. The outcome for patients with silent ischemia has not been well established.

Prevention

A healthy lifestyle, including eating a well-balanced diet,getting regular exercise, maintaining a healthy weight, not smoking, drinking in moderation, not using illegal drugs, controlling hypertension, and managing stress are practices that can reduce the risk of ischemia progressing to a heart attack or stroke.

A healthy diet includes a variety of foods that are low in fat (especially saturated fat), low in cholesterol, and high in fiber. Plenty of fruits and vegetables should be eaten and sodium intake should be limited.

Fat should comprise no more than 30% of total daily calories. Cholesterol should be limited to about 300 mg and sodium to about 2,400 mg per day.

Moderate aerobic exercise lasting about 30 minutes four or more times per week is recommended for maximum heart health, according to the Centers for Disease Control and Prevention and the American College of Sports Medicine.

Three 10-minute exercise periods also are beneficial. If any risk factors are present, a physician’s clearance should be obtained before starting exercise.

Maintaining a desirable body weight also is important. People who are 20% or more over their ideal body weight have an increased risk of developing coronary artery disease or stroke.

Smoking has many adverse effects on the heart and arteries, and should be avoided. Heart damage caused by smoking can be improved by quitting. Several studies have shown that ex-smokers face the same risk of heart disease as nonsmokers within five to ten years after quitting.

Excessive drinking can increase risk factors for heart disease. Modest consumption of alcohol, however, can actually protect against coronary artery disease. The American Heart Association defines moderate consumption as one ounce of alcohol per day—roughly one cocktail, one 8-oz glass of wine, or two 12-oz glasses of beer.

Commonly used illegal drugs can seriously harm the heart and should never be used. Even stimulants like ephedra and decongestants like pseudoephedrine can be harmful to patients with hypertension or heart disease.

Treatment should be sought for hypertension. High blood pressure can be completely controlled through lifestyle changes and medication. Stress, which can increase the risk of a heart attack or stroke, should also be managed. While it cannot always be avoided, it can be controlled.

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